# Instinctive Raw Paleodiet ## Denatured molecules Egypt before the pharaohs---Gigal Research : https://gigalresearch.com/uk/publications-pharaohs.php Vlassara, H., Uribarri, J. Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both? (2014) : https://doi.org/10.1007/s11892-013-0453-1 Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice (2019) : https://doi.org/10.1155/2019/2746521 Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts (1998) : https://doi.org/10.1007/s007020050069 Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals (2011) : https://doi.org/10.1016/j.mad.2011.10.007 Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects (2020) : https://doi.org/10.1155/2020/3818196 Ageing, age-related diseases and oxidative stress: What to do next? (2019) : https://doi.org/10.1016/j.arr.2019.100982 Age-Related Reduction of NO Availability and Oxidative Stress in Humans, Stefano Taddei & al (2001) : https://ahajournals.org/doi/full/10.1161/01.HYP.38.2.274 Advanced Glycation End Products and Risks for Chronic Diseases: Intervening Through Lifestyle Modification (2017) : https://doi.org/10.1177/1559827617708991 Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease (2017) : https://doi.org/10.3390%2Fnu9040385 Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects (2020) : https://doi.org/10.1155/2020/3818196 Dietary advanced glycation end-products: Perspectives linking food processing with health implications (2020) : https://doi.org/10.1111/1541-4337.12593 The advanced glycation end product N(epsilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney disease and hypertension (2006) : https://pubmed.ncbi.nlm.nih.gov/16997053/ Potential reactions of thermal process contaminants during digestion (2020) : https://sciencedirect.com/science/article/abs/pii/S0924224420306373?via%3Dihub Impact of telomere attrition on diabetes mellitus and its complications (2023) : https://doi.org/10.1016/j.deman.2023.100174 Association between telomere length and diabetes mellitus: A meta-analysis (2016) : https://doi.org/10.1177/0300060516667132 Shorter Telomere Length in Carriers of APOE-ε4 and High Plasma Concentration of Glucose, Glyoxal and Other Advanced Glycation End Products (AGEs) (2020) : https://doi.org/10.1093/gerona/glz203 Dietary Advanced Glycation End products interacting with the intestinal epithelium: What do we really know? (2023) : https://sciencedirect.com/science/article/pii/S2212877823000686#bib6 Dietary advanced glycation end-products: Perspectives linking food processing with health implications (2020) : https://doi.org/10.1111/1541-4337.12593 Tissue-resident memory T cells populate the human brain (2018) : https://doi.org/10.1038/s41467-018-07053-9 Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs (2016) : https://doi.org/10.1038/srep27848 Melanin and facial skin fluorescence as markers of yellowish discoloration with aging (2009) : https://doi.org/10.1111/j.1600-0846.2009.00396.x Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet (2010) : https://doi.org/10.1016/j.jada.2010.03.018 ### Fat storage of denatured molecules Plasma advanced glycation end products are decreased in obese children compared with lean controls (2009) : https://doi.org/10.1080/17477160802248039 Fat Mass Is Inversely Associated with Serum Carboxymethyl-Lysine, An Advanced Glycation End Product, in Adults (2011) : https://doi.org/10.3945%2Fjn.111.143172 Obesity and Systemic Oxidative Stress, Clinical Correlates of Oxidative Stress in The Framingham Study (2003) : https://ahajournals.org/doi/abs/10.1161/01.ATV.0000058402.34138.11 Oxidative stress, AGE, and atherosclerosis (2007) : https://doi.org/10.1038/sj.ki.5002382 Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation End Product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and Insulin Resistance (2014) : https://doi.org/10.1161/ATVBAHA.113.302281 Adipokines Mediate Inflammation and Insulin Resistance (2013) : https://ncbi.nlm.nih.gov/pmc/articles/PMC3679475/ An Advanced Glycation End Product (AGE)-Receptor for AGEs (RAGE) Axis Restores Adipogenic Potential of Senescent Preadipocytes through Modulation of p53 Protein Function (2012) : https://pubmed.ncbi.nlm.nih.gov/23150674/ Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice (2013) : https://pubmed.ncbi.nlm.nih.gov/23011593 Advanced Glycation End-products accelerate amyloid deposits in adipocyte’s lipid droplets (2023) : https://doi.org/10.1101/2023.11.06.565836 Advanced glycation end products modulate electrophysiological remodeling of right ventricular outflow tract cardiomyocytes: A novel target for diabetes‐related ventricular arrhythmogenesis (2022) : https://ncbi.nlm.nih.gov/pmc/articles/PMC9630757/ ## Defining the natural diet Snow Monkey diet -- Minnesota Zoo : https://mnzoo.org/blog/animals/snow-monkey/ ### About insects and meat Aquatic versus savanna: comparative and paleo-environmental evidence : https://doi.org/10.1177/026010609300900304 Human gastric juice contains chitinase that can degrade chitin (2007) : https://doi.org/10.1159/000104144 What tree-climbing pygmies tell us about foot evolution -- National-Geographic : https://nationalgeographic.com/science/article/what-tree-climbing-pygmies-tell-us-about-foot-evolution moving quickly from branches to branches (brachiation) : https://evolvemoveplay.com/movement-inspiration-8-14-14-brachiation/ Global hunter-gatherer population densities constrained by influence of seasonality on diet composition (2021) : https://nature.com/articles/s41559-021-01548-3 ### Learning instincts as a child In Vitro Fertilization Technology and Child Health (2020) : https://ncbi.nlm.nih.gov/pmc/articles/PMC7026576/#:~:text=The%20risks%20of%20heart%20defects,but%20also%20on%20IVF%20itself. Evolution of the Human Life (2020) : https://doi.org/10.1017/9781108379977.005 ## Degraded mind and body Increased prevalence of transglutaminase 6 antibodies in sera from schizophrenia patients (2013) : https://pubmed.ncbi.nlm.nih.gov/22516148/ Wheat Gluten as a Pathogenic Factor in Schizophrenia (1976) : https://doi.org/10.1126/science.1246624 Use of a Gluten-Free Diet in Schizophrenia: A Systematic Review (2018) : https://ncbi.nlm.nih.gov/pmc/articles/PMC6247287/ Sugar-and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia (2017) : https://doi.org/10.1161/STROKEAHA.116.016027 Sugary beverage intake and preclinical Alzheimer's disease in the community (2017) : https://doi.org/10.1016/j.jalz.2017.01.024 Is Soda Bad for Your Brain? (And Is Diet Soda Worse?) : https://bu.edu/articles/2017/soda-bad-for-brain/ almost superhuman healing factor : https://youtube.com/watch?v=-CkWmgL0k00 ### Rawfood practionners and body fat Consequences of a Long-Term Raw Food Diet on Body Weight and Menstruation: Results of a Questionnaire Survey (1998) : https://doi.org/10.1159/000012770 A squirrel his thousands of walnuts under the hood of a man’s truck. It wasn’t the first time : https://washingtonpost.com/nation/2021/09/30/squirrel-truck-fargo-bill-fischer/ ## Origin of cooking Catching Fire : /Images/images_article_instincto/catching_fire_wrangham_book.jpg On the earliest evidence for habitual use of fire in Europe (2011) : https://pnas.org/doi/10.1073/pnas.1018116108 On the evidence for human use and control of fire at Schöningen (2015) : https://sciencedirect.com/science/article/abs/pii/S0047248415000858 How Did Hominins Adapt to Ice Age Europe without Fire? (2017) : https://core.ac.uk/download/365177119.pdf apes : https://pubmed.ncbi.nlm.nih.gov/29417991/ Autofluorescence of experimentally heated bone: Potential archaeological applications and relevance for estimating degree of burning (2020) : https://doi.org/10.1016/j.jasrep.2020.102333 Gluten and dairy are like addictive drugs to the brain : https://thefnc.com/research/gluten-and-dairy-are-like-addictive-drugs-to-the-brain/ Which Foods May Be Addictive? The Roles of Processing, Fat Content, and Glycemic Load (2015) : https://doi.org/10.1371/journal.pone.0117959 Mozambican Grass Seed Consumption During the Middle Stone Age (2009) : https://pnas.org/content/106/27/10966 Great apes prefer cooked food (2008) : https://doi.org/10.1016/j.jhevol.2008.03.003 ## Deregulated breeding ### Abnormal life history Reproductive aging in captive and wild common chimpanzees: factors influencing the rate of follicular depletion : https://doi.org/10.1002/ajp.20650 Evolutionary Perspective on Human Growth (1999) : https://jstor.org/stable/223390 Breastfeeding and timing of pubertal onset in girls: a multiethnic population-based prospective cohort study (2019) : https://doi.org/10.1186/s12887-019-1661-x Little or no breastfeeding : https://doi.org/10.1186/s12887-019-1661-x Human growth and development among high-altitude populations in 'The Biology of high altitude peoples' (1978) : https://annas-archive.org/md5/f57b1e9787d7120b205e097e99fb9168 Tibetans : https://pubmed.ncbi.nlm.nih.gov/6614862/ First period tied to girl's weight -- Reuters (2011) : https://reuters.com/article/us-first-period-tied-girl-weight-idUSTRE72G82J20110317 Evolutionary Perspective on Human Growth (1999) : https://jstor.org/stable/223390 The evolution of the adolescent growth spurt: Urinary biomarkers of bone turnover in wild chimpanzees (Pan troglodytes) (2023) : https://doi.org/10.1016/j.jhevol.2023.103341 Evolutionary Perspective on Human Growth (1999) : https://jstor.org/stable/223390 Evidence for adolescent length growth spurts in bonobos and other primates highlights the importance of scaling laws (2023) : https://doi.org/10.7554/eLife.86635.3 Why humans---and so few other animals---have periods ? : https://eusci.org.uk/2020/04/09/why-do-humans-and-so-few-other-animals-have-periods/ Seasonal Variations in Food Supply for Wild Primates (1988) : https://hal.science/hal-00578690/document ### New reality with raw food Oogenesis in adult mammals, including humans: a review (2005) : https://doi.org/10.1385/ENDO:26:3:301 Neurons for Ejaculation and Factors Affecting Ejaculation (2022) : https://doi.org/10.3390/biology11050686 Concerning female ejaculation and the female prostate (1978) : http://dx.doi.org/10.1080/00224497809550988 ### About cooking ### Meat Rollet: La révolution française aurait-elle contribué à avancer l’âge de la puberté des filles ? (translated) (2015) : https://doi.org/10.3917/ethn.154.0607 Rollet: La révolution française aurait-elle contribué à avancer l’âge de la puberté des filles ? (translated) (2015) : https://doi.org/10.3917/ethn.154.0607 year long study in Bwindi Impenetrable Forest : https://doi.org/10.1007/s00442-007-0901-1 Mountain gorilla – Wikipedia : https://en.wikipedia.org/wiki/Mountain_gorilla A Day in The Life of The Gorilla Section at Port Lympne Reserve, The Aspinall Foundation : https://blog.aspinallfoundation.org/a-day-in-the-life-of-the-gorilla-section-at-port-lympne-reserve Historical sampling reveals dramatic demographic changes in western gorilla populations (2011) : https://doi.org/10.1186/1471-2148-11-85 Fruit-feeding and activity patterns of mountain gorillas (Gorilla beringei beringei) in Bwindi Impenetrable National Park, Uganda (2020) : https://eva.mpg.de/documents/Wiley-Blackwell/Ostrofsky_Fruit-feeding_AmJPhysAnthr_2020_3221596.pdf Diet of Grauer’s Gorillas in the Montane Forest of Kahuzi, Democratic Republic of Congo (2005) : https://doi.org/10.1007/s10764-005-8856-8 Dietary variability of western gorillas (Gorilla gorilla gorilla) (2022) : https://doi.org/10.1371/journal.pone.0271576 What Do Gorillas Eat? : https://a-z-animals.com/blog/what-do-gorillas-eat/ Gorilla diet in the Lope Reserve, Gabon: a nutritional analysis (1990) : https://doi.org/10.1007/bf00329756 Mortality rates among wild chimpanzees, 2001 : https://doi.org/10.1006/jhev.2001.0469 Favorable ecological circumstances promote life expectancy in chimpanzees similar to that of human hunter-gatherers (2017) : https://dx.doi.org/10.1016/j.jhevol.2017.01.003 Natural mortality and cause of death analysis of the captive chimpanzee: a 35 year review : https://doi.org/10.1111%2Fjmp.12267 Risk factors for respiratory illness in a community of wild chimpanzees (2018) : https://royalsocietypublishing.org/doi/10.1098/rsos.180840 Forests Help Make Clouds, And Together They Cool The Earth : https://iflscience.com/forests-help-make-clouds-and-together-they-cool-the-earth-60607 2022, How primate research was hijacked by sexist ideologues : https://theatlantic.com/magazine/archive/2022/06/ape-gender-frans-de-waal-lucy-cooke/629637/ ## A new theoretical model of the viral phenomenon ### Preface, by the author ### Classical model of the viral phenomenon ### Classical model of viral disease ### Viral diseases and Burger’s experiment ### Proposal of a new theoretical model of the viral phenomenon ### Discussion ### Origin of the virus ### Membrane receptors ### Viral membrane and cell membrane. ### Similarity between viral DNA or RNA and cellular DNA ### Reverse transcriptase ### Replication of viroids ### Viral multiplication ### Cellular lysis ### Genetic variability ### Plant viruses ### The role of interferon ### Autoimmune mechanisms ### Perfection of virion structures ### Conservation of viral information ### Bacterial Symbiosis ### Apoptosis ### Difference in evolution ### childhood diseases ### Changes in the biotope ### Antivirals ### Oncogenic viruses ### AIDS ### Afterwords # A fallen world ## Health in the wild ### Rape and violence Abnormal behaviors induced by chemical pollution: a review of the evidence and new challenges (2004) : https://doi.org/10.1016/j.anbehav.2004.01.005 ### A global propaganda effort bottom of the world : https://education.nationalgeographic.org/resource/plastic-bag-found-bottom-worlds-deepest-ocean-trench genetic legacy from violent ancestors : https://en.wikipedia.org/wiki/Demonic_Males ## Comparing wild and zoo apes ### Mountain gorillas Skeletal and Dental Pathology of Free-Ranging Mountain Gorillas (G. b. beringei) (1990) : https://doi.org/10.1002/ajpa.1330810309 Gorilla World—What do gorillas eat? Gorilla Feeding & Diet : https://gorillas-world.com/gorilla-feeding/ up to 17% considering an upper limit of 190kg : https://wildgorillasafaris.com/facts-about-gorilla-facts/how-much-does-a-gorilla-eat-per-day captivity : https://gorillafacts.org/how-much-does-a-gorilla-weigh/ 275 kg : https://en.wikipedia.org/wiki/Western_lowland_gorilla 310 kg : https://africangorilla.com/information/mountain-gorilla-size-height-weight/ A Day in The Life of The Gorilla Section at Port Lympne Reserve, The Aspinall Foundation : https://blog.aspinallfoundation.org/a-day-in-the-life-of-the-gorilla-section-at-port-lympne-reserve Seaworld : https://seaworld.org/animals/all-about/gorilla/diet/ Nutrition in Primates, last modification: 2022 : https://msdvetmanual.com/management-and-nutrition/nutrition-exotic-and-zoo-animals/nutrition-in-primates actually love fruits and meat : https://bestofpanda.com/do-giant-pandas-eat-fruit/ Low level of anthropization linked to harsh vertebrate biodiversity declines in Amazonia (2022) : https://doi.org/10.1038/s41467-022-30842-2 Mayaro Virus in Wild Mammals, French Guyana (2003) : https://doi.org/10.3201%2Feid0910.030161 ### Shortened lifespans ### Other epidemics Recent loss of closed forests is associated with Ebola virus disease outbreaks (2017) : https://nature.com/articles/s41598-017-14727-9 Ebola has wiped out a third of the population of chimps and gorilla (2015) : https://phys.org/news/2015-01-ebola-virus-population-chimps-gorillas.html Both Angola and the Democratic Republic of the Congo Experiencing High Numbers of Agricultural Fires (2O2O) : https://www.nasa.gov/image-article/both-angola-democratic-republic-of-congo-experiencing-high-numbers-of-agricultural-fires/ Epidemics in Populations of Wild Ruminants: Anthrax and Impala, Rinderpest and Buffalo in Lake Manyara National Park, Tanzania (1997) : https://jstor.org/stable/3565551 ## Justifying wars Chimpanzee violence is a serious topic: A response to Sussman and Marshack’s critique of Demonic Males: Apes and the Origins of Human Violence : http://nonkilling.org/pdf/wp1.pdf overestimated : https://newscientist.com/article/dn23895-vendettas-not-war-unpicking-why-our-ancestors-killed/ Anthropologist Brian Ferguson Challenges Claim that Chimp Violence is Adaptive (2014) : https://unl.edu/rhames/War/Anthropologist%20Brian%20Ferguson%20Challenges%20Claim%20that%20Chimp%20Violence%20is%20Adaptive%20_.pdf Chimpanzees, War, and History: Are Men Born to Kill (2023) : https://doi.org/10.1093/oso/9780197506752.001.0001 Robert Sussmann : https://doi.org/10.1093/acprof:oso/9780199858996.003.0006 Extremely High Frequency of Promiscuous Mating of Female Chimpanzees Observed in the Kalinzu Forest, Uganda, Intra‑community infanticide in wild, eastern chimpanzees: a 24‑year review (2019) : https://doi.org/10.2354/psj.19.17 ## Justifying addictions Is sugar really as addictive as cocaine? Scientists row over effect on body and brain (2017) : https://theguardian.com/society/2017/aug/25/is-sugar-really-as-addictive-as-cocaine-scientists-row-over-effect-on-body-and-brain Tools to tipple: ethanol ingestion by wild chimpanzees using leaf-sponges (2015) : https://doi.org/10.1098/rsos.150150 Analysis of spontaneous alcohol drinking in rhesus monkeys (1989) : https://doi.org/10.1016/0031-9384(90)90077-h Effects of red wine on accelerated gastric emptying following Nissen fundoplication (2020) : https://dx.doi.org/10.1136/jim-2020-001436 The appetizing effect of an apéritif in overweight and normal-weight humans (1999) : https://pubmed.ncbi.nlm.nih.gov/9989681/ the New York Times, in 2018 : https://nytimes.com/2018/10/07/science/drunk-birds-gilbert-minnesota.html Alcohol accumulation from ingested berries and alcohol metabolism in passerine birds 1982 : https://lintulehti.birdlife.fi:8443/pdf/artikkelit/778/tiedosto/of_60_2-9_artikkelit_778.pdf Strong circumstantial evidence for ethanol toxicosis in Cedar Waxwings (Bombycilla cedrorum) (2012) : https://doi.org/10.1007/s10336-012-0858-7 Suspected Ethanol Toxicosis in Two Wild Cedar Waxwings (1990) : https://pubmed.ncbi.nlm.nih.gov/2369387/ Drunk robins: It’s a myth that those birds are drunk on berries (2009) : https://eastbaytimes.com/2009/12/24/gary-bogue-drunk-robins-its-a-myth-that-those-birds-are-drunk-on-berries/ # Modern confirmations ## Exosomes and viruses Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi (2015) : https://doi.org/10.1038/nrmicro3480 Extracellular membrane vesicles in the three domains of life and beyond (2019) : https://doi.org/10.1093/femsre/ Outer Membrane Vesicles (OMVs) of Gram-negative Bacteria: A Perspective Update (2017) : https://doi.org/10.3389/fmicb.2017.01053 Bacterial Outer Membrane Vesicles: From Discovery to Applications (2021) : https://annualreviews.org/content/journals/10.1146/annurev-micro-052821-031444 Extracellular vesicles: An emerging platform in gram-positive bacteria (2020) : https://doi.org/10.15698%2Fmic2020.12.737 Protein selection and export via outer membrane vesicles (2014) : https://doi.org/10.1016/j.bbamcr.2013.12.011 Bacteriolytic effect of membrane vesicles from Pseudomonas aeruginosa on other bacteria including pathogens: conceptually new antibiotics (1996) : https://doi.org/10.1128/jb.178.10.2767-2774.1996 Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles (2010) : https://doi.org/10.1128/mmbr.00031-09 Offense and defense: microbial membrane vesicles play both ways (2012) : https://doi.org/10.1016/j.resmic.2012.10.020 Stress-induced outer membrane vesicle production by Pseudomonas aeruginosa (2013) : https://doi.org/10.1128/jb.02267-12 Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs (2013) : https://doi.org/10.1038/ncomms3980 Degenerate consensus sequences in the 3′-untranslated regions of cellular mRNAs as specific motifs potentially involved in the YB-1-mediated packaging of these mRNAs (2020) : https://doi.org/10.1016/j.biochi.2020.01.005 Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release (1991) : https://doi.org/10.1073/pnas.88.8.319 ## Tiny genomes, incredibly complex mechanisms Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells (2007) : https://doi.org/10.1038/ncb1596 Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes (2013) : https://tandfonline.com/doi/full/10.3402/jev.v2i0.20677 Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016) : https://doi.org/10.1007/s10571-016-0366-z Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016) : https://doi.org/10.1007/s10571-016-0366-z Intravacuolar Pathogens Hijack Host Extracellular Vesicle Biogenesis to Secrete Virulence Factors (2021) : https://doi.org/10.3389/fimmu.2021.662944 clonal selection in secondary lymphoid organs : https://fr.wikipedia.org/wiki/Hypermutation_somatique Extracellular vesicles are the Trojan horses of viral infection (2016) : https://sciencedirect.com/science/article/pii/S1369527416300595 ## Neuro­degenerative diseases Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats (1997) : https://ncbi.nlm.nih.gov/pmc/articles/PMC1858286/ Detection of the receptor for advanced glycation endproducts in neuronally-derived exosomes in plasma (2018) : https://doi.org/10.1016/j.bbrc.2018.04.181 Differential effects of glycation on protein aggregation and amyloid formation (2014) : https://10.3389/fmolb.2014.00009 Brain clearance of protein aggregates, a close-up on astrocytes, Giusti, V., Kaur, G., Giusto, E. et al. (2024) : https://doi.org/10.1186/s13024-024-00703-1 Using reporters of different misfolded proteins reveals differential strategies in processing protein aggregates (2022) : https://doi.org/10.1016%2Fj.jbc.2022.102476 Extensive accumulation of misfolded protein aggregates during natural aging and senescence : https://ncbi.nlm.nih.gov/pmc/articles/PMC9909609/ Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells (2012) : https://doi.org/10.1371/journal.pone.0034653 ## About pathogen-driven selection Gene conversion rapidly generates major histocompatibility complex diversity in recently founded bird population (2001) : https://doi.org/10.1111/j.1365-294X.2011.05367.x Genetic Association between Swine Leukocyte antigen Class II Haplotypes and Reproduction Traits in Microminipigs (2019) : https://doi.org/10.3390/cells8080783