# Uncovering our past ## We, Neandertals ### The Out-Of-Africa nonsense never peer-reviewed : https://prehistoric-britain.co.uk/blackhenge-debunking-the-media-misinterpretation-of-the-stonehenge-builders ### Mitochondrial Eve coalescent theory : https://en.wikipedia.org/wiki/Coalescent_theory Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males Versus Females (2013) : https://doi.org/10.1126/science.1237619 The Simons Genome Diversity Project: 300 genomes from 142 diverse populations (2016) : https://doi.org/10.1038/nature18964 The Eve Hypotheses: A Genetic Critique and Reanalysis (1993) : https://jstor.org/stable/681179 Phylogenetic congruence, conflict and consilience between molecular and morphological data (2023) : https://doi.org/10.1186/s12862-023-02131-z Dates from the molecular clock: how wrong can we be? (2006) : https://doi.org/10.1016/j.tree.2006.11.013 Erratic mitochondrial clock variations of mutation rate, not population size, affect mtDNA diversity across birds and mammals (2009) : https://doi.org/10.1186/1471-2148-9-54 Evolution of human mitochondrial DNA: Evidence for departure from a pure neutral model of populations at equilibrium (1990) : https://link.springer.com/article/10.1007/BF02099939 The maximum genetic diversity theory of molecular evolution (2023) : https://academia.edu/123153593/The_maximum_genetic_diversity_theory_of_molecular_evolution Inverse relationship between genetic diversity and epigenetic complexity (2009) : https://doi.org/10.1038/npre.2009.1751.2 Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes (2025) : https://science.org/doi/10.1126/science.ads7951 Non-coding RNA: what is functional and what is junk? (2015) : https://doi.org/10.3389/fgene.2015.00002/full Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA (2019) : http://dx.doi.org/10.1101/101410 Neandertal DNA and modern humans (2008) : https://creationresearch.org/crsq-2009-volume-45-number-4_neandertal-dna-and-modern-humans The Neandertal mitochondrial genome does not support evolution (2009) : https://creation.com/neandertal-mitochondrial-genome ### Antiracist conspiracy Genomic analysis of a novel Neanderthal from Mezmaiskaya Cave provides insights into the genetic relationships of Middle Palaeolithic populations (2022) : https://nature.com/articles/s41598-022-16164-9 A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) : https://nature.com/articles/s41598-019-44877-x ## Cooking and neoteny ### Multiregional origins The Tabun Cave and Paleolithic Man in the Levant (1982) : https://ww.jstor.org/stable/1689660 Genomic structure in Europeans dating back at least 36,200 years (2014) : https://doi.org/10.1126/science.aaa0114 Mean Intracranial Volume of Brain among Patients with Normal Magnetic Resonance Imaging Referred to the Department of Radiology and Imaging of a Tertiary Care Centre (2023) : https://pmc.ncbi.nlm.nih.gov/articles/PMC10792718/ Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (2019) : https://doi.org/10.1186/s13195-019-0506-z 7.2 million-Year-Old Pre-Human Fossil A Challenge to Out of Africa? (2020) : https://ancient-origins.net/human-origins-science/mankind-arose-europe-not-africa-021987 Hominin presence in Eurasia by at least 1.95 million years ago (2025) : https://www.nature.com/articles/s41467-025-56154-9 Semicircular canals shed light on bottleneck events in the evolution of the Neanderthal clade (2024) : https://doi.org/10.1038/s41467-025-56155-8 ### Autodomestication through cooking Variation in cross-sectional indicator of femoral robusticity in Homo sapiens and Neandertals (2022) : https://doi.org/10.1038/s41598-022-08405-8 Mrs. Marie Cachet : https://mariecachet.wordpress.com/2012/09/26/2-glaciations-and-migration-hybridization-and-survival-en/ produce back Neanderthal skulls : https://digitalcommons.cedarville.edu/icc_proceedings/vol4/iss1/12 ### The start of cooking New Data on the Late Neandertals: Direct Dating of the Belgian Spy Fossils (2025) : https://research.rug.nl/files/6730585/2009AmJPhysAnthropolSemal.pdf Earliest modern human genomes constrain timing of Neanderthal admixture (2O24) : https://nature.com/articles/s41586-024-08420-x ### Apparences and reconstructions Una nuova approx­ssimazione facciale per l’Uromo de la Chapelle-aux-Saints 1 (2023) : https://doi.org/10.13140/RG.2.2.33164.08326 A Race-By-Race Breakdown of Human Genetic Diversity: Illustrated Guide for Novices -- Thuletide (2022) : https://thuletide.wordpress.com/2020/06/29/a-race-by-race-breakdown-of-human-genetic-diversity-illustrated-guide-for-novices/ ### Muscular attachments How Strong were the Neandertals? Leverage and Muscularity at the Shoulder and Elbow in Mousterian (2006) : https://academia.edu/1439962/How_strong_were_the_Neandertals_Leverage_and_muscularity_at_the_shoulder_and_elbow_in_Mousterian_foragers The shanidar neanderthals,p.43 (1983) : https://annas-archive.org/md5/7482183d48e22cd358f979779e84fdf6 Cheap labor: myosin fiber type expression and enzyme activity in the forelimb musculature of sloths (Pilosa: Xenarthra) (2018) : https://doi.org/10.1152/japplphysiol.01118.2017 Neandertal energetics: Uncertainty in body mass estimation limits comparisons with Homo sapiens (2015) : https://doi.org/10.1016/j.jhevol.2015.04.007 Femoral curvature in Neanderthals and modern humans: A 3D geometric morphometric analysis (2011) : https://doi.org/10.1016/j.jhevol.2010.09.009 ## Lifespan and ontogeny ### Passage of time or genetic programming Supraorbital morphology and social dynamics in human evolution (2018) : https://doi.org/10.1038/s41559-018-0528-0 Masticatory Loading and Bone Adaptation in the Supraorbital Torus of Developing Macaques (2009) : https://doi.org/0.1002/ajpa.20972 The Supraorbital Torus: \"A Most Remarkable Peculiarity\" [and Comments and Replies] (1985) : http://jstor.org/stable/2742733 The question of robusticity and the relationship between cranial size and shape in Homo sapiens (1996) : https://doi.org/10.1006/jhev.1996.0056 A Geographic Cline of Skull and Brain Morphology among Individuals of European Ancestry (2011) : https://doi.org/10.1159/000330168 ### Implications of the possibility of longer lifespans The evolution of cranial form in mid-Pleistocene Homo (2012) : http://dx.doi.org/10.4102/sajs.v108i3/4.719 Origins and evolution of extreme lifespan in Pacific Ocean rockfishes (2021) : https://pmc.ncbi.nlm.nih.gov/articles/PMC8923369/ Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation (2023) : https://www.science.org/doi/10.1126/sciadv.add2743 Somatic mutation as an explanation for epigenetic aging (2025) : https://doi.org/10.1038/s43587-024-00794-x Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations (2024) : https://doi.org/10.1016/j.arr.2024.102268 On aging and age-specific effects of spontaneous mutations (2023) : https://academic.oup.com/evolut/article/77/8/1780/7169332 A Theory of Age-Dependent Mutation and Senescence (2008) : https://pmc.ncbi.nlm.nih.gov/articles/PMC2516080/ Empirical verification of evolutionary theories of aging (2016) : https://aging-us.com/article/101090/text The Mechanism of Programmed Aging: The Way to Create a Real Remedy for Senescence (2020) : https://pmc.ncbi.nlm.nih.gov/articles/PMC7403645/ ### Neandertals and cooking Neanderthal Medics? Evidence for Food, Cooking, and Medicinal Plants Entrapped in Dental Calculus (2012) : https://doi.org/10.1007/s00114-012-0942-0 ### Modern strategies to downplay brain size differences New insights into differences in brain organization between Neanderthals and anatomically modern humans (2013) : https://royalsocietypublishing.org/doi/full/10.1098/rspb.2013.0168 Latitudinal variation in light levels drives human visual system size (2011) : https://doi.org/10.1098/rsbl.2011.0570 Latitudinal variation in light levels drives human visual system size, supplementary materials : https://royalsocietypublishing.org/action/downloadSupplement?doi=10.1098%2Frsbl.2011.0570&file=rsbl20110570supp1.pdf 20% of the brain doing visual processing : https://spinozacentre.nl/dumoulin/PDFs/Wandell-Encyclopedia-2009.pdf Is baseline pupil size related to cognitive ability? Yes (under proper lighting conditions) (2021) : https://doi.org/10.1016/j.cognition.2021.104643 The evolutionary mystery of gigantic human brains (2018) : https://arstechnica.com/science/2018/08/the-evolutionary-mystery-of-gigantic-human-brains/ ### Meat and isotopic profiles Midden or Molehill: The Role of Coastal Adaptations in Human Evolution and Dispersal (2019) : https://doi.org/10.1371/journal.pone.0186684 A Neandertal dietary conundrum: Insights provided by tooth enamel Zn isotopes from Gabasa, Spain (2017) : https://doi.org/10.1073/pnas.2109315119 Exceptionally high δ15N values in collagen single amino acids confirm Neandertals as high-trophic level carnivores (2019) : https://doi.org/10.1073/pnas.1814087116 The diet-body offset in human nitrogen isotopic values: A controlled dietary study : https://doi.org/10.1002%2Fajpa.22140 Body size predicts ontogenetic nitrogen stable-isotope (δ15N) variation, but has little relationship with trophic level in ectotherm vertebrate predators (2024) : https://doi.org/10.1038/s41598-024-61969-5 metabolic processing over time : https://pmc.ncbi.nlm.nih.gov/articles/PMC5108472/ Nitrogen isotope fractionation in a continuous culture system containing phytoplankton and blue mussels (2019) : https://pmc.ncbi.nlm.nih.gov/articles/PMC7036703/ Comparing the assimilation of dietary nitrogen supplied by animal-, plant- and microbial-derived ingredients in Pacific white shrimp Litopenaeus vannamei: A stable isotope study (2020) : https://doi.org/10.1016/j.aqrep.2020.100294 A new era of isotope ecology: Nitrogen isotope ratio of amino acids as an approach for unraveling modern and ancient food web (2023) : https://doi.org/10.2183/pjab.99.009 Isotopic Nitrogen-15 Labeling of Mice Identified Long-lived Proteins of the Renal Basement Membranes (2020) : https://doi.org/10.1038/s41598-020-62348-6 Can heavy isotopes increase lifespan? Studies of relative abundance in various organisms reveal chemical perspectives on aging (2016) : https://pmc.ncbi.nlm.nih.gov/articles/PMC5108472/ Australopithecus at Sterkfontein did not consume substantial mammalian meat (2025) : https://doi.org/10.1126/science.adq7315 Putrid Meat and Fish in the Eurasian Middle and Upper Paleolithic: Are We Missing a Key Part of Neanderthal and Modern Human Diet (2017) : https://doi.org/10.4207/PA.2017.ART105 Alternatives to Neanderthal Hypercarnivory - Experimental Study of the δ15N Values of Meat During Putrefaction (2018) : https://ui.adsabs.harvard.edu/abs/2018AGUFM.B53K2204F/ Middle Pleistocene Homo behavior and culture at 140,000 to 120,000 years ago and interactions with Homo sapiens (2021) : https://science.org/doi/10.1126/science.abh3020 Isotopes in early South African hominin teeth show they ate little meat (2025) : https://phys.org/news/2025-01-isotopes-early-south-african-hominin.html ## Antediluvian civilizations World’s Largest Monolith: Yangshan Monument Created by a Lost Ancient Civilization? : https://youtube.com/watch?v=SP5RwRkkn2k&list=PL92SXkFO15Cyy2_UEApzB0ghgR5fcDOsT Proof a Mysterious Lost Ancient GLOBAL Civilization Spanned Virtually the Entire Planet… -- Youtube : https://youtube.com/watch?v=BTd1fRCAvR4 Response to Why World of Antiquity Doesn't Believe In Advanced Lost Civilization DeDunking Debunked -- Youtube : https://youtube.com/watch?v=XzDbhVDlhjU&t=3s&ab_channel=DeDunking Petra: Incredibly Advanced Tool Marks Tell a Different Story -- Curious Being : https://youtube.com/watch?v=PCgdVAHsQ_w The Thunder Stone: from 1,500 down to 400 tons – Jiri Mruzek : https://grahamhancock.com/phorum/read.php?1,1049641,1049641 Jupiter's Temple, Baalbek, Lebanon, by Jiri Mruzek : http://vejprty.com/baalbek.htm The Tiny Ancient Artifacts Changing History! Ancient Egyptian Hard Stone Vases - Huge Updates -- UnchartedX : https://youtube.com/watch?v=YqGoaWPzxd0&t The Secret of Ancient Tools: METAL MICROPARTICLE research - VERSADOCO : https://youtube.com/watch?v=bkrmM_AlryQ 15 Reasons why Khufu did NOT build the Great Pyramid : https://academia.edu/45014007/15_Reasons_why_Khufu_did_NOT_build_the_Great_Pyramid Great Pyramids’ Radiocarbon Dating: An Inconvenient Truth : https://youtube.com/watch?v=UgLuLd_4B18 UnchartedX channel -- Youtube : https://youtube.com/@UnchartedX Andean Megalithic Technology -- Youtube : https://youtube.com/@andeanmegalithictechnology3525 Cosmic TUSK : https://cosmictusk.com/category/younger-dryas-impact-evidence/ ### Addressing criticisms Why the Megalithic Andean Architecture in Peru and the Sacred Valley is older than the INCA! : https://youtube.com/watch?v=oxuiB1vhDjM&list=PLb1MDIWaJM6nDgVIUbIOlIaUK4znWK-Fy Microstructural Evidence of Reconstituted Limestone Blocks in the Great Pyramids of Egypt (2006) : https://doi.org/10.1111/j.1551-2916.2006.01308.x Are Pyramids Made Out of Concrete? : https://geopolymer.org/archaeology/pyramids/pyramids-2-the-evidences/ deep overcuts : https://youtu.be/ixTTvRGk0HQ?t=3183 manufactured stones : https://youtube.com/watch?v=QJWmZVhI_K4&ab_channel=AndeanMegalithicTechnology power-tools : https://youtube.com/watch?v=d8Ejf5etV5U Ancient Quarry Mount Nokogiri Excavated by Prehistoric Machines or Hand Tools? : https://youtube.com/watch?v=5kq8CFI7WXQ ### Contradictions to the laws of historical development The sky's the limit: human powered cranes and lifting devices : https://lowtechmagazine.com/2010/03/history-of-human-powered-cranes.html#more ### A magic-based machinery ### Beginning and end of an era Extraordinary Biomass-Burning Episode and Impact Winter Triggered by the Younger Dryas Cosmic Impact ∼12,800 Years Ago. 2. Lake, Marine, and Terrestrial Sediments (2018) : https://doi.org/10.1086/695704 ## Gods of Legends ### Higher brain functions 5 Mind-Blowing Things Kim Peek Could Do That You Can’t -- AppliedBehaviorAnalysisEdu.org : https://appliedbehavioranalysisedu.org/5-mind-blowing-things-kim-peek-could-do-that-you-cant/ Agenesis of the Corpus Callosum (ACC) -- Cleveland Clinic : https://my.clevelandclinic.org/health/diseases/6029-agenesis-of-the-corpus-callosum-acc Kim Peek, Inspiration for ‘Rain Man,’ Dies at 58 (2009) -- NY times : https://nytimes.com/2009/12/27/us/27peek.html Brumblay, R.J. Hyperdimensional Perspectives in Out-of-Body and Near-Death Experiences (2003) : https://doi.org/10.1023/A:1024054029979 48 hours without rest : https://trailrunnermag.com/people/culture/the-lung-gom-pa-runners-of-old-tibet/?scope=anon ### Reimagining love [C. K. Sharpe, Law’s Memoriall (1818) : https://play.google.com/books/reader?id=Lk5BAQAAMAAJ&pg=GBS.PR19.w.1.2.0_682&hl=fr increasingly so, video games : https://youtube.com/watch?v=MrZgnidmYUc ### Unlimited power at our fingertips ### a magical world The Faerie Phenomenon in Folkloric and Modern Experience -- Neil Rushton : https://grahamhancock.com/rushtonn1/ Avoid the deep woods, here's why -- What Lurks Beneath : https://youtube.com/watch?v=zyb4xHCkxbk ### Our crucial ecological function # Genetics ## The laws of heredity QTL : https://en.wikipedia.org/wiki/Quantitative_trait_locus Evidence of evolutionary forces leading to the spread of lethal genes in wild population of house mice (1957) : https://doi.org/10.1073/pnas.43.1.158 ### The quantal structure of DNA Epistasis - Wikipedia : https://en.wikipedia.org/wiki/Epistasis Analysis of Haplotype Sequences (2015) : https://doi.org/10.5772/61794 Multi-SNP Analysis of MHC Region: Remarkable Conservation of HLA-A1-B8-DR3 Haplotype (2006) : https://doi.org/10.2337/db05-1276 Analysis of Haplotype Sequences (2015) : https://doi.org/10.5772/61794 Commentary: Conserved polymorphic sequences protect themselves for future challenges (2022) : https://doi.org/10.3389/fgene.2022.993944 Speciation of Genes and Genomes: Conservation of DNA Polymorphism by Barriers to Recombination Raised by Mismatch Repair System (2022) : https://doi.org/10.3389/fgene.2022.803690 Analysis of Haplotype Sequences (2015) : https://doi.org/10.5772/61794 Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms (2011) : https://doi.org/10.1016/j.humimm.2010.12.005 Major Histocompatibility Complex (MHC) in Health and Disease (2020) : https://mdpi.com/books/reprint/2011-major-histocompatibility-complex-mhc-in-health-and-disease Genomic evolution in domestic cattle: Ancestral haplotypes and healthy beef (2011) : https://doi.org/10.1016/j.ygeno.2011.02.006 ### Adaptations are intelligent and endogenous Soma to germline inheritance of extrachromosomal genetic information via a LINE-1 reverse transcriptase-based mechanism (2016) : https://doi.org/10.1002/bies.201500197 Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes (2014) : https://doi.org/10.1371/journal.pone.0101629 Lindley et al, How Evolution Occurs: Was Lamarck Also Right. EdgeScience, 8, 6-9 (2011) : https://scientificexploration.org/edgescience/8 Analysis of Haplotype Sequences, Sally S. Lloyd, Edward J. Steele and Roger L. Dawkins (2015) : https://dx.doi.org/10.5772/61794 Soma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC: The manifest polymorphism of the MHC appears greatly exceeded at Immunoglobulin loci, suggesting antigen-selected somatic V mutants penetrate Weismann's Barrier (2015) : https://europepmc.org/article/MED/25810320 Somatic mutation patterns at Ig and Non-Ig Loci (2024) : https://doi.org/10.1016/j.dnarep.2023.103607 Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR (2019) : https://doi.org/10.1111%2Fsji.12853 Germline V repertoires: Origin, maintenance, diversification, Steele, E. J., & Lindley, R. A. (2018) : https://doi.org/10.1111/sji.12670 Stress responses and genetic variation in bacteria (2004) : https://doi.org/10.1016/j.mrfmmm.2004.07.017 Gene conversion-like events in the diversification of human rearranged IGHV3-2301 gene sequences : https://doi.org/10.3389/fimmu.2012.00158 Heterozygosity of H–2 loci in wild mice (1979) : https://doi.org/10.1038/281603a0 What evolutionary processes maintain MHC IIꞵ diversity within and among populations of stickleback? (2021) : https://doi.org/10.1111/mec.15840 The importance of immune gene variability (MHC) in evolutionary ecology and conservation (2005) : https://doi.org/10.1186/1742-9994-2-16 Monomorphism and polymorphism at Mhc DRB loci in domestic and wild ruminants (1999) : https://doi.org/10.1111/j.1600-065x.1999.tb01390.x Genesis of ancestral haplotypes: RNA modifications and reverse transcription–mediated polymorphisms (2021) : https://doi.org/10.1016/j.humimm.2010.12.005 Molecular Lamarckism: on the evolution of human intelligence (2017) : https://doi.org/10.1080/02604027.2017.1319669 ### Short-circuiting natural selection Standard Deviations: The Biological Bases of Transmission Ratio Distortion (2019) : https://doi.org/10.1146/annurev-genet-112618-043905 Evaluating the Evidence for Transmission Distortion in Human Pedigrees (2012) : https://doi.org/10.1534/genetics.112.139576 Evidence for Extensive Transmission Distortion in the Human Genome (2004) : https://doi.org/10.1086/381131 Selfish genetic elements (2018) : https://doi.org/10.1371/journal.pgen.1007700 Transmission ratio distortion: review of concept and implications for genetic association studies (2013) : https://doi.org/10.1007/s00439-012-1257-0 Drive and sperm the evolution and genetics of male meiotic drive (2009) : https://doi.org/10.1016/B978-0-12-372568-4.00012-4 The Ecology and Evolutionary Dynamics of Meiotic Drive : http://dx.doi.org/10.1016/j.tree.2016.02.001 Within-Ejaculate Sperm Selection and Its Implications for Assisted Reproduction Technologies (2021) : https://doi.org/10.1007/978-3-030-66292-9_20 Do sperm possess a molecular passport? Mechanistic insights into sperm selection in the female reproductive tract ? (2015) : https://doi.org/10.1093/molehr/gav012 The role of the tumor suppressor p53 in spermatogenesis (1998) : https://doi.org/10.1038/sj.cdd.4400396 Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes (2018) : https://doi.org/10.1111/evo.13591 The Magic That Happens When a Sperm Meets an Egg and the Sparks Fly : https://idahofertility.com/the-magic-that-happens-when-a-sperm-meets-an-egg-and-the-sparks-fly/ Haploid selection within a single ejaculate increases offspring fitness (2017) : https://doi.org/10.1073/pnas.1705601114 Male transmission ratio distortion supports MHC-linked cryptic female choice in the lesser kestrel (Aves: Falconidae) (2012) : https://doi.org/10.1007/s00265-012-1401-9 Chromatin-unstable boar spermatozoa have little chance of reaching oocytes in vivo (2018) : https://doi.org/10.1530/rep-07-0333 Do sperm possess a molecular passport? Mechanistic insights into sperm selection in the female reproductive tract ? (2015) : https://doi.org/10.1093/molehr/gav012 Cryptic female choice - Wikipedia : https://en.wikipedia.org/wiki/Cryptic_female_choice Sperm variation within a single ejaculate affects offspring development in Atlantic salmon (2014) : https://ncbi.nlm.nih.gov/pmc/articles/PMC3949374/ Exosomes and exosomal non‑coding RNAs throughout human gestation (2022) : https://doi.org/10.3892/etm.2022.11518 3.2. Inheritance of acquired neonatal tolerance to foreign histocompatibility antigens in mice - Lamarck and Panspermia, On the Efficient Spread of Living Systems Throughout the Cosmos (2019) : https://doi.org/10.1016/j.pbiomolbio.2019.08.010 Crossovers are associated with mutation and biased gene conversion at recombination hotspots (2014) : https://doi.org/10.1073/pnas.1416622112 ### Genetic fixity versus fluidity To Supplement or Not to Supplement: Are Inuit Getting Enough Vitamin D? (2019) : https://erudit.org/en/journals/etudinuit/2016-v40-n2-etudinuit04225/1055442ar/ genetic hitchhiking : https://en.wikipedia.org/wiki/Genetic_hitchhiking ## In defense of inbreeding Studies on inbreeding, I. The effects of inbreeding on the growth and variability in the body weight of the albino rat (1918) : https://ia800708.us.archive.org/view_archive.php?archive=/28/items/crossref-pre-1923-scholarly-works/10.1002%252Fjctb.5000412409.zip&file=10.1002%252Fjez.1400260102.pdf Inbreeding Effects on Layer Performance at Two Levels of Protein Intake (1980) : https://doi.org/10.3382/ps.0591155 Phylo Metabolomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice (2008) : https://doi.org/10.1371/journal.pone.0001668 Effect of diet on spontaneous disease in the inbred mouse strain C57B1/10J (1985) : https://doi.org/10.1016/0378-4274(85)90072-4 Influence of heredity on response of inbred rats to diet: I. Differences in body size, food intakes, incidence of spontaneous kidney defects, kidney weights, urine pH and protein (1967) : https://doi.org/10.1016/0026-0495(67)90027-3 Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice (2021) : https://doi.org/10.1111/acel.13500 Local adaptation, coadaptation and population boundaries (1986) : https://doi.org/10.1002/zoo.1430050206 Inbreeding, Incest, And The Incest Taboo The State of Knowledge at the Turn of the Century, from Arthur P. Wolf : https://annas-archive.org/md5/b8a7a2ee87656155e2c1a71a3bf37ef5 The Incest Taboo and the Mating Patterns of Animals (1963) : https://jstor.org/stable/667441 Inbreeding and broodstock management -- FAO : https://fao.org/4/x3840e/X3840E00.htm ### The theoretical cost of inbreeding An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans (2015) : https://doi.org/10.1534%2Fgenetics.114.173351 Inbreeding Coefficient (2016) : https://link.springer.com/referenceworkentry/10.1007/978-1-4020-6754-9_8397 The effect of reproductive compensation on recessive disorders within consanguineous human populations (2002) : https://doi.org/10.1038/sj/hdy/6800090 The effect of inbreeding rate on fitness, inbreeding depression and heterosis over a range of inbreeding coefficients (2014) : https://doi.org/10.1111%2Feva.12145 Local adaptation, coadaptation and population boundaries (1986) : https://doi.org/10.1002/zoo.1430050206 Elimination of inbreeding depression in a captive herd of Speke's gazelle (1984) : https://doi.org/10.1002/zoo.143003032 Mutation rate variability as a driving force in adaptive evolution (2019) : https://doi.org/10.1103%2FPhysRevE.99.022424 Mutation Patterns in the Human Genome: More Variable Than Expected (2009) : https://doi.org/10.1371/journal.pbio.1000028 Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome (2020) : https://doi.org/10.1038/s41467-020-15185-0 Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges (2022) : https://doi.org/10.1038/s41467-022-32353-6 Erratic mitochondrial clock variations of mutation rate, not population size, affect mtDNA diversity across birds and mammals (2009) : https://doi.org/10.1186/1471-2148-9-54 Natural Selection Resisting Inbreeding Depression in Captive Wild House Mice (1979) : https://doi.org/10.2307/2407656 Genomic consequences of intensive inbreeding in an isolated wolf population (2017) : https://nature.com/articles/s41559-017-0375-4 Strikingly high levels of heterozygosity despite 20 years of inbreeding in a clonal honey bee (2022) : https://doi.org/10.1111/jeb.13397 Transposable elements maintain genome-wide heterozygosity in inbred populations (2022) : https://doi.org/10.1038%2Fs41467-022-34795-4 Phenotype of the Cyp1a1/1a2/1b1(−/−) Triple-Knockout Mouse (2009) : https://doi.org/10.1124/mol.108.045658 Pseudogenes: Pseudo-functional or key regulators in health and disease? (2011) : https://ncbi.nlm.nih.gov/pmc/articles/PMC3078729/ Inbreeding Depression in the Speke’s Gazelle Captive Breeding Program (1999) : https://montana.edu/kalinowski/documents/2000_Spekes_gazelle_inbreeding_ConservationBiology.pdf Mutations Beget More Mutations-Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation (2020) : https://pubmed.ncbi.nlm.nih.gov/31778175/ ### Heterotic selection and HFC Understanding the relationship between the inbreeding coefficient and multilocus heterozygosity, theoretical expectations and empirical data (2004) : https://doi.org/10.1038/sj.hdy.6800485 Heterozygosity-fitness correlations and their relevance to studies on inbreeding depression in threatened species (2008) : https://doi.org/10.1111/j.1365-294x.2008.03910.x Do infectious diseases drive MHC diversity ? 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